What is Exemestane 25 (Astera Labs)?
Astera Labs exemestane in 25mg tablets, 50 to a sachet. The aromatase inhibitor that binds permanently, so stopping it does not rebound estrogen.
Also sold as Aromasin, Exemestan or exemestane.
Exemestane is a steroidal aromatase inhibitor and it works differently from the others here. Rather than competing for the enzyme, it binds to it permanently and takes it out of service, so your body has to build new aromatase to recover. That is why it is described as a suicidal inhibitor, and it is why stopping it does not produce the estrogen rebound the non-steroidal ones can.
Exemestane 25 benefits
- Binds aromatase irreversibly, so there is no estrogen rebound when you stop
- Kinder to cholesterol than anastrozole or letrozole
- No interaction with tamoxifen, so it is the right aromatase inhibitor to pair with a SERM
- Mildly androgenic in its own right rather than purely an anti-estrogen
- 25mg tablets, which is a standard dose with nothing to split
Exemestane 25 dosage
- Common starting point
- 12.5mg every other day, half a tablet
- Standard
- 25mg every other day
- Higher end
- 25mg daily
- Adjust from
- An estradiol blood test, not from symptoms
- Half-life
- About 24 hours
- Post-cycle therapy
- Do not use, switch to a SERM
12.5mg every other day is a sensible starting point and plenty of people never need more.
Adjust from a blood test. High and low estrogen produce almost identical symptoms, so dosing by feel usually means overshooting.
Package content
- Tablets
- 50 per sachet
- Strength
- 25mg exemestane per tablet
- Exemestane per sachet
- 1250mg
- Half-life
- About 24 hours
- Brand
- Astera Labs
At 12.5mg every other day one sachet covers around 200 days.
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Who is Exemestane 25 for?
Anyone who wants estrogen control without rebound, anyone running tamoxifen alongside, and anyone whose lipids are already a concern.
AROMAMED 25 is the same 25mg strength from Deus Medical in a boxed blister.
How to use Exemestane 25
Swallow with water after food, which improves absorption noticeably with this compound. Every other day is the usual schedule. Stop it when the cycle ends.



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